Page Title
Clinical Fruit Trial
                                                Weight loss associated with a daily intake of three apples or three pears among overweight women.
                                                                                        Conceição de Oliveira M, Sichieri R, Sanchez Moura A.
                                                           Instituto de Medicina Social, State University of Rio de Janeiro, Rio de Janeiro, Brazil.


 OBJECTIVE: We investigated the effect of fruit intake on body weight change. METHODS: Hypercholesterolemic, overweight (body mass index >
25 kg/m2), and non-smoking women, 30 to 50 y of age, were randomized to receive, free of charge, one of three dietary supplements: apples, pears,
or oat cookies. Women were instructed to eat one supplement three times a day in a total of six meals a day. Participants (411 women) were recruited
at a primary care center of the State University of Rio de Janeiro, Brazil. Fifty-one women had fasting blood cholesterol levels greater than 6.2 mM/L
(240 mg/dL) and 49 were randomized. Subjects were instructed by a dietitian to eat a diet (55% of energy from carbohydrate, 15% from protein, and
30% from fat) to encourage weight reduction at the rate of 1 kg/mo. RESULTS: After 12 wk of follow-up, the fruit group lost 1.22 kg (95%
confidence interval = 0.44-1.85), whereas the oat group had a non-significant weight loss of 0.88 kg (0.37-2.13). The difference between the two
groups was statistically significant (P = 0.004). To explore further the body weight loss associated with fruit intake, we measured the ratio of glucose
to insulin. A significantly greater decrease of blood glucose was observed among those who had eaten fruits compared with those who had eaten oat
cookies, but the glucose:insulin ratio was not statistically different from baseline to follow-up. Adherence to the diet was high, as indicated by
changes in serum triacylglycerols, total cholesterol, and reported fruit intake. Fruit intake in the oat group throughout treatment was minimal.

CONCLUSIONS: Intake of fruits may contribute to weight loss.
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Clinical Fruit Trial